Islington Avenue is a north-south route travelling through the City of Toronto and York Region.

At the end of the Second World War the street was widened, causing the loss of almost all historic buildings.

At Dundas Street, is historic Montgomery's Inn, built in 1832, and now operated as a museum by the City of Toronto.

It continues north through a series of nieghbourhoods of suburban Etobicoke including Richview, Kingsview Village, and Rexdale.

North of Steeles Avenue it enters the city of Vaughan, and passes through the communities of Woodbridge and Pine Grove before terminating at Highway 27 at the former town of Kleinburg.