In enzymology, an isochorismatase (EC 3.3.2.1) is an enzyme that catalyzes the chemical reaction Thus, the two substrates of this enzyme are isochorismate and H2O, whereas its two products are 2,3-dihydroxy-2,3-dihydrobenzoate and pyruvate.
This enzyme belongs to the family of hydrolases, specifically those acting on ether bonds (ether hydrolases).
The systematic name of this enzyme class is isochorismate pyruvate-hydrolase.
This enzyme participates in the biosynthesis of siderophore group (nonribosomal).
As of late 2007, 3 structures have been solved for this class of enzymes, with PDB accession codes 1NF8, 1NF9, and 2FQ1.