It was located along the Seinäjoki–Vaasa railway, and its neighboring stations at the time of closing were Ylistaro in the east and Tervajoki in the west.

[3] Isokyrö was opened under the name of Orismala at the same time as the rest of the Seinäjoki–Vaasa line, on 29 September 1883.

It was established in the crossing between the railway and the road from the Isokyrö Church to the Orisberg Manor, being named after the latter.

[3] Isokyrö remained as a passenger station until 20 June 2016, when it was closed along with Laihia and Ylistaro.

The company then established a replacement bus service to serve the surroundings the closed stations.