Issinsky District (Russian: Иссинский райо́н) is an administrative[1] and municipal[5] district (raion), one of the twenty-seven in Penza Oblast, Russia.

It is located in the north of the oblast.

The area of the district is 926.3 square kilometers (357.6 sq mi).

[2] Its administrative center is the urban locality (a work settlement) of Issa.

[8] The population of Issa accounts for 48.6% of the district's total population.