is a 220-mile (350 km) tributary of the Colville River in the North Slope Borough of the U.S. state of Alaska.

[3] The river flows northeast then northwest out of the Endicott Mountains near Oohlah Pass to meet the larger stream about 25 miles (40 km) southwest of Harrison Bay on the Beaufort Sea.

[1] An Iñupiaq map, drawn in about 1900, identifies the river as It-kil-lik, meaning Indian.

[3] A melting permafrost formation exposed along the Itkillik River is the largest known yedoma in Alaska.

Odors emitted by the gasses released when the ice thaws have led to the site's nickname, the Stinking Hills or Stinky Bluffs.