Clark High School was constructed at 1100 East Leo Street in Opelousas.

[14] It was named after Joseph Samuel Clark, the first president of Southern University and a key contributor to the founding of the National Urban League.

[14] The U.S. Supreme Court decision Brown v. Board of Education (1954) ruled school segregation to be unconstitutional, but the state of Louisiana delayed ending the practice.

Clark High School colors were maroon and white, and the mascot was a bulldog.

Alumni include Olympic gold medal winning hurdler Rodney Milburn.