These are responsible for demethylation of tri- and di-methylated lysines in the 4 position of histone 3 (H3K4me3 and H3K4me2).

[8] Jarid1B has been implicated in the development of prostate, breast, and skin cancer and also has been associated with melanoma maintenance.

It also acted to decrease serum estrogen levels and caused reduced mammary epithelial cell proliferation in the early stages of puberty.

[9] However, others have shown that a Jarid1B knockout embryos usually have neonatal lethality due to the failure of their respiratory system.

[11] This article incorporates text from the United States National Library of Medicine, which is in the public domain.