Leading citizens — primarily physicians and lawyers — proposed that an institution of higher learning be established, which led to the founding of the private, nonsectarian University of Buffalo.

In 1893, the school relocated to High Street in the city, where it remained until 1953, when it moved to the university's South Campus.

It moved in 2017 to a new campus on High and Main Streets, again adjacent to the Buffalo General Hospital complex.

Today's network of teaching affiliations was formalized in 1983 as the Graduate Medical Dental Education Consortium of Buffalo.

[3] UB has affiliations with almost every major hospital in the city of Buffalo for its educational and research objectives.