His father, who is African-American was a computer programmer and software consultant and his mother, who is Polish-American worked as a teacher.

[4] In Loney's senior year, his high school team was ranked first in the nation by Baseball America and won the 5A state championship.

[6] He was named to the Texas Sports Writers Association 5A all-state team at the end of the 2002 baseball season, as well as Powerade and Gatorade Player of the Year.

[10] Loney began his professional career in 2002 with the Great Falls Dodgers, where he hit .371 and was named the top prospect in the Pioneer League by Baseball America.

However, he had an injury plagued season at Double-A Jacksonville and fell to #42 on Baseball America's prospect list.

[12][14] In 2005, Loney led the Southern League Champion Jacksonville Suns in hits and total bases.

He was named the Dodgers Minor League Player of the Year and was chosen as first-team Triple-A All-Star First Baseman by Baseball America.

[28] He set a career high with five hits on September 18, helping the Dodgers win three straight games against the Pittsburgh Pirates.

[30] On August 25, 2012, he was traded to the Boston Red Sox (along with Iván DeJesús, Jr., Allen Webster, Jerry Sands and Rubby De La Rosa) for Adrián González, Josh Beckett, Carl Crawford and Nick Punto and $11 million in cash.

[32] On July 23, 2013, Loney collected his 1,000th career hit in a game versus his former team, the Boston Red Sox.

[33][34] The contract wound up being a good deal for Loney and the Rays, as he hit .299 with 13 home runs and 75 RBIs, his best numbers since his rookie season in 2007.

[35] His numbers dipped a bit in 2014, as he hit .290 with 9 home runs and 69 RBIs, but he had 600 at-bats in a season for the first time in his career.

[39] He played in 43 games for the AAA El Paso Chihuahuas, including one appearance as a relief pitcher.

On January 24, 2017, Loney signed a minor league contract with the Texas Rangers that included an invitation to spring training.

[49] On February 5, 2019, Loney signed with the Sugar Land Skeeters of the Atlantic League of Professional Baseball.