James Ruse Drive is a 6.4-kilometre-long (4.0 mi)[1] limited-access urban highway located to the east and north of Parramatta, in Western Sydney, New South Wales, Australia.

The road was named in honour of James Ruse, a convict who was given land in the Parramatta district, which he successfully developed into the colony's first sustainable farm.

A pre-stressed concrete bridge was built over the Parramatta River to link Aston Street and Rydalmere Avenue, completed in 1966.

[10] The eastern half of the Parramatta Bypass (along Berry and Aston Streets, and Rydalmere Avenue and its new extensions to Windsor Road) was named as James Ruse Drive on 2 February 1981.

[3] In July 1994, as part of a grade separation project, a bridge was built over James Ruse Drive at Rydalmere to eliminate the intersection with Victoria Road.