Southern Cross Drive is a 4.8 km (3 mi) dual carriage untolled motorway in Sydney, New South Wales, Australia.

Southern Cross Drive commences at the interchange with South Dowling Street (and the southern end of Eastern Distributor, around 500m beyond) and Link Road and heads south as a 6-lane, dual-carriageway road, tracing past the western border of The Australian Golf Club in Kensington and through The Lakes Golf Club in Eastlakes, before turning westwards over Wentworth Avenue towards the eastern boundary of Sydney Airport, where it turns south again to eventually merge with General Holmes Drive.

It allows a continuous link from M5 Motorway, General Holmes Drive, Westlink M7, Eastern Distributor, Cahill Expressway, Sydney Harbour Tunnel, Sydney Harbour Bridge, Warringah Freeway, Gore Hill Freeway, Lane Cove Tunnel and M2 Hills Motorway.

[5] A road project to extend Southern Cross Drive further south-west as an elevated roadway over Wentworth Avenue, Botany and Mill Pond Roads – and over reclaimed swampland including Mill Pond, Mill Steam, and Botany Dams, much of which has been reclaimed for golf courses (including the Eastlakes Golf Club, The Lakes Golf Club and Bonnie Doon Golf Club) – to connect directly to General Holmes Drive on the eastern border of Sydney Airport, opened in February 1988.

[12] There were plans to construct south-facing ramps from Gardeners Road to Southern Cross Drive, proposed in 2005.