He is best known for writing the films Zodiac (2007),[4] The Amazing Spider-Man (2012) and its 2014 sequel, and Independence Day: Resurgence (2016).
Vanderbilt also contributed as producer for several films, including The House with a Clock in Its Walls (2018) and Ready or Not (2019).
[5] His paternal great-grandfather Alfred Gwynne Vanderbilt Sr. died on the RMS Lusitania in the 1915 sinking, his paternal grandfather, Alfred Gwynne Vanderbilt Jr., once chaired the New York Racing Association, and his maternal grandfather, Donald Campbell Platten, was the chief executive and chairman of Chemical Bank.
[9] In May 2016, Mythology acquired intellectual property rights to Slender Man from the character's creator Eric Knudsen.
In 2020, Vanderbilt co-wrote the script for the fifth installment of the Scream franchise, starring Neve Campbell, David Arquette, Courteney Cox, Melissa Barrera, Jenna Ortega, Jack Quaid, Marley Shelton, Dylan Minnette, Mason Gooding, Kyle Gallner, Jasmin Savoy Brown, Mikey Madison and Sonia Ben Ammar.