A native of Napoleonville, Louisiana,[2] Milazzo earned a Bachelor of Arts degree in 1977 from Nicholls State University.

[3] She then earned a Juris Doctor in 1992 from Louisiana State University's Paul M. Hebert Law Center.

[3] She then began working in 1986 as a paralegal for a Napoleonville, Louisiana law firm.

[3][4] On March 16, 2011, President Barack Obama nominated Milazzo to fill a seat on the United States District Court for the Eastern District of Louisiana that had been vacated by Judge Mary Ann Vial Lemmon, who assumed senior status on January 1, 2011.

[5] On October 11, 2011, the United States Senate confirmed Milazzo by a 98–0 vote.