Jesús Enrique Lossada covers an area of 3,533 square kilometres (1,364 sq mi)[1] and recorded a population of 118,756 in the 2011 Venezuelan census.

[2] It is named after Jesús Enrique Lossada [es] (1892–1948), a distinguished lawyer, politician, professor, and writer from Maracaibo.

The relief in the eastern part of the municipality is flat, while in the west it elevates to form the mountains of the Serranía del Perijá on the Colombia–Venezuela border.

The Palmar River, on which the Tres Ríos Reservoir is located, forms the municipal border between Jesús Enrique Lossada and Rosario de Perijá.

[4] Troncal 6 highway passes through the southeastern corner of the municipality as it runs between Villa del Rosario in the southwest and San Francisco in the east.

The Tres Ríos Reservoir is located at the confluence of the Palmar, Lajas and Caño Pescado rivers on the border between Jesús Enrique Lossada and Rosario de Perijá.