His lab develops AI/ML methods to study the structure and function of the human genome[5] and cellular organization and their implications for health and disease.

[6] His research group has recently pioneered a series of new machine learning solutions for 3D genome organization, single-cell epigenomics, spatial omics, and complex molecular interactions.

His lab also explores large language models to uncover gene regulatory mechanisms and the intricate connections among cellular components, with the aim of driving discovery and guiding experimentation.

[12] He leads an NIH 4D Nucleome Center to develop machine learning algorithms to better understand the cell nucleus.

[16] In 2024, he launched the Center for AI-Driven Biomedical Research (AI4BIO) at CMU, which will be a catalyst for innovations at the intersection of AI and biomedicine across the School of Computer Science and campus.