[6] From 2005 Amupanda studied at the University of Namibia (UNAM) where he graduated with a bachelor's degree in political science, and from 2008 served as the president of the Students' Council where he gained popularity during his tenure.
[citation needed] In 2015, Amupanda started lecturing political science at his alma mater UNAM.
[11] Amupanda was first introduced to youth leadership when he was elected to the UNAM SRC in 2007 as secretary for information and publicity.
After his expulsion from the party, Amupanda formed the Affirmative Repositioning movement to advocate for land and other issues affecting youths in Namibia.
[13][14] Amupanda has represented the Windhoek Council as a member of the Board of Directors of the Association of Local Authorities in Namibia (ALAN) since April 2022.
[16][17] Amupanda holds political admiration for Burkina Faso's Thomas Sankara, Zimbabwe's former president Robert Mugabe, South Africa's Steve Biko, Robert Sobukwe, and Julius Malema, leader of the Economic Freedom Fighters.
[18] In November 2014, Amupanda, Dimbulukeni Nauyoma, and George Kambala, all of the SWAPO Youth League, occupied land in the affluent Klein Windhoek suburb as a means to demand land in the city, and in response to reports of corruption by the Windhoek municipality.
[25] 'As you are aware, attempts are being made to [...] reduce me into a jacket, a consequence and extension of other people's opinion.
On 2 December, following months of campaigning, he was elected Mayor of the city after the opposition voted in his favor to lead the municipality.