In 2008, Zeitz introduced PUMAVision, an ethical framework defined by the four key principles of being fair, honest, positive and creative as applied to all professional behaviour, business procedures and relationships throughout and outside of Puma.

[11] In May 2011 he announced Puma's Environmental Profit & Loss Account,[12] which puts a monetary value to a businesses use of ecosystem services across the entire supply chain.

Known for “proven turnaround” skills Zeitz assumed the helm of Harley-Davidson first as interim CEO in February 2020 and took over the job permanently in May 2020, succeeding Matthew S. Levatich.

In December 2021, Zeitz announced LiveWire, the electric-motorcycle division of Harley-Davidson, will become a separate publicly traded company to "operate with the same agility and speed as a startup."

[14] On the day of listing, Zeitz was the first CEO to ring the opening and closing bell of trading on the NYSE, also being the first to run two public-listed companies.

[15][16] Zeitz's turnaround plan at Harley, was aimed at revitalizing the company as a premium brand and was considered a success story through the first half of 2024.

[17][18] In 2008 Zeitz founded the not-for-profit Zeitz Foundation for Intercultural Ecosphere Safety to support creative and innovative sustainable projects and solutions that balance conservation, community development, culture, and commerce (the "4Cs") in a quadruple bottom line approach, promoting an inclusive, holistic paradigm of conservation that enhances livelihoods and fosters intercultural dialogue while building sustainable businesses.

Safeguarding over 21 million acres of nature in 22 different countries, touching the lives of over 750,000 people and protecting over 30,000 plant and animal species, The Long Run has become the largest organisation of its kind worldwide.

In 2014, Thomas Heatherwick was chosen to design the conversion of the 1920s granary into a museum, including 80 galleries, 18 education rooms, a rooftop sculpture garden as well as storage and conservation areas, a restaurant, a coffee shop, and bookstores.

In 2014 Zeitz co-wrote and published The Breakthrough Challenge: 10 Ways to Connect Today's Profits with Tomorrow's Bottom Line with John Elkington.

This documentary film, narrated by Sir David Attenborough, breaks down the climate thresholds needed for the survival of the planet and humanity.

The ten-minute trailer was screened to world leaders at the Biden Climate Summit in April 2021, and was released globally on Netflix in June 2021.

Set within Kenya’s Maasai homeland, an intimate and contemporary story of self-discovery unfolds as 12 women become East Africa’s first all-female anti-poaching unit.

Upending the male-dominated world of military-style ranger training, these women instead undergo an extensive program of deep trauma-release and healing, triggering profound transformation within themselves and sending shockwaves through their communities.