His brother JT plays for the Denver Outlaws of the Premier Lacrosse League.

[10] On September 5, 2020, Giles-Harris was waived by the Jaguars and signed to the practice squad the next day.

[17] In Week 14 against the Tennessee Titans, Giles-Harris recorded his first career sack on Ryan Tannehill during the 31–10 loss.

[21][22] After the Bills were eliminated in the Divisional Round of the 2021 playoffs, he signed a reserve/future contract on January 24, 2022.

[33] On December 24, 2024, Giles-Harris was signed by the Jacksonville Jaguars off the Bengals practice squad.