On October 12, 2020, Syracuse head coach Dino Babers announced that Cisco would miss the remainder of the season due to a torn ACL.

He instead remained listed as active and was able to compete against Andrew Wingard, Daniel Thomas, Josh Jones, Jarrod Wilson, Rudy Ford to be the starting strong safety under defensive coordinator Joe Cullen throughout training camp.

"[16] On September 12, 2021, Cisco made his professional regular season debut in the Jacksonville Jaguars' season-opener at the Houston Texans, but was limited to one solo tackle during the 21–37 loss.

[23] On December 26, 2021, Cisco earned his first career start and recorded five combined tackles (two solo) and had one pass break up during a 21–26 loss at the New York Jets.

He finished his rookie campaign in 2021 with a total of 26 combined tackles (19 solo), two pass deflections, and two forced fumbles while appearing in all 17 games with three starts.

[24] During training camp, Cisco competed against Andrew Wingard to be the starting safety under defensive coordinator Mike Caldwell.

[25] Head coach Doug Pederson named Cisco the starting free safety to begin the season, alongside Rayshawn Jenkins.

He finished his sophomore season with a total of 73 combined tackles (49 solo), ten pass deflections, three interceptions, and one sack while starting all 15 games he appeared in.

The following week, he made four combined tackles (three solo) as the Jaguars were eliminated from the playoffs after losing 20–27 at the Kansas City Chiefs in the Divisional Round.

[29] On September 10, 2023, he started in the Jacksonville Jaguars' season-opener at the Indianapolis Colts and collected a season-high ten combined tackles (seven solo) in their 31–21 victory.

He finished the 2023 NFL season with a total of 62 combined tackles (42 solo), five pass deflections, four interceptions, and was credited with half a sack in 15 games and 15 starts.

[36] In Week 6, Cisco made seven combined tackles (three solo) and intercepted a pass by Caleb Williams during a 16–35 loss at the Chicago Bears.