[13] John F. Kennedy Memorial High School offers a variety of Advanced Placement (AP) courses designed to provide students with college-level academic challenges and the opportunity to earn college credit.

The John F. Kennedy Memorial High School Mustangs[2] compete in the Greater Middlesex Conference, which is comprised of public and private high schools located in the greater Middlesex County area, operating under the supervision of the New Jersey State Interscholastic Athletic Association (NJSIAA).

[20][21] The softball team won the Group III state championship in 1988, defeating runner-up Ramsey High School in the tournament finals.

[23][24] The boys' soccer team won the 2005 Central Jersey Group II state sectional championship with a victory over Roselle Park High School, the first soccer state title in the school's history, and earning Ed Bobal honors from the Home News Tribune as its coach of the year.

[25] The softball team won the 2007 North II Group III state sectional championship with a 2–1 win over South Plainfield High School.

[26] The team repeated as the 2008 North II Group III state sectional champions with a 5–0 win in the tournament final over crosstown rival Colonia High School.