The new building replaced a previous facility completed in 1971 that was operating in excess of capacity.

The average class size is 24 students, with Special Education courses meeting state standards.

The School Based Youth Services Program is designed to concern the social issues and health needs of students, and is sponsored by the Jewish Renaissance Foundation and the Perth Amboy Board of Education.

There are also many school clubs which students can propose or start themselves, and run if they find an advisor.

The school also has a Concert and Marching Band, which plays many parades throughout the year and during football season.

The Perth Amboy High School Panthers[2] compete in the Greater Middlesex Conference, which is comprised of public and private high schools in the Middlesex County area and operates under the supervision of the New Jersey State Interscholastic Athletic Association (NJSIAA).

[12] The football team competes in Division 5C of the Big Central Football Conference, which includes 60 public and private high schools in Hunterdon, Middlesex, Somerset, Union and Warren counties, which are broken down into 10 divisions by size and location.

[14] Led by Brian Taylor, the 1968 boys basketball team won the Group IV state championship, defeating Neptune High School by a score of 72-70 in the tournament final at Atlantic City's Convention Hall.

Core members of the school's administration include the principals, as well as four vice principals at the main campus and two at the Freshman Academy:[18] Notable alumni of Perth Amboy High School include: