[1] It is known for being the first site approved to use cell-based gene therapy to treat patients with certain types of large B-cell lymphoma who have not responded or relapsed after at least two other kinds of treatment; it initiated the first CAR T-cell therapy clinical trials and is a member of the NCI-approved Georgetown Lombardi Comprehensive Cancer Center.

Other areas of concentration include bone marrow transplants, stem cell transplantation, lymphoma, leukemia, multiple myeloma, neuro-oncology, cutaneous malignancy, gastrointestinal, geriatric, head and neck, thoracic, urologic, breast, and gynecologic.

The center provides comprehensive medical and surgical oncology/hematology consultative services by community-based, regional, and national specialists for various types and stages of cancer and serious blood disorders.

[13] In 2022, JTCC entered into a clinical affiliation with St. Joseph's Health to provide expanded cancer care services to the residents of Wayne, Paterson, and Totowa.

[1] The JTCC pavilion was built with a green roof, providing patients and visitors with a relaxing environment[16] and doubling as exterior insulation—greatly reducing heat gain and loss.