He is an Associate Professor of Biomedical Engineering at Johns Hopkins University, where he sits at the Center for Imaging Science.

His group develops and applies high-dimensional nonlinear machine learning methods to biomedical data science challenges.

They have published over 100 papers in prominent scientific and engineering journals and conferences including Nature, Science, PNAS, Neurips, and JMLR, with over 10,000 citations and an h-index over 40.

Specifically, his work often focuses on big and wide data in neuroscience, and in particular on the statistics of brain graphs and connectomics.

[16] Joshua Vogelstein has been on the advisory board for numerous commercial companies, including Gigantum, Mind-X, and PivotalPath.