Klausner is head writer and co-executive producer of the Web series Billy on the Street, also starring Eichner, which had previously run on Funny or Die, Fuse, and TruTV and now premieres on Lyft's website and YouTube.

[8][9] As an actor, Klausner has also appeared in several comedy series in addition to Difficult People, such as Netflix's Big Mouth and TruTV's At Home with Amy Sedaris, and as Cheryl in Emmy and Golden Globe Award-winning FX miniseries Fosse/Verdon.

In October 2011, NBC picked up a pilot based on the Sue Margolis novel Apocalipstick, about a woman's father who dates her high-school nemesis, which Klausner was to write and serve as executive producer.

[10] In March 2018, it was announced Klausner would co-star in the NBC comedy pilot So Close, about two hopeless romantics unaware they live only blocks apart and may be soulmates.

In March 2020, Klausner joined the writing staff of Amazon Prime Video's revival of the sketch comedy show Kids in the Hall.

[16] In March 2020, Klausner and comedian-author Tom Scharpling premiered their podcast Double Threat, which they cohost on the Forever Dog network.