[2] In 2000, Macklowe worked with Chase Capital Management (now JPMorgan Partners) in Seoul and Hong Kong, where she helped structure leverage buyouts.
[9] In an interview the following year, she said, "I haven’t looked at a stock since the day I left.”[10] In December 2010, Macklowe's first fashion industry investment, BaubleBar, launched with help from Accel Partners.
[13][14][15] Vbeauté started as a luxury, travel-friendly toiletry kit that meets TSA regulations for carry on luggage and was developed by CRB Cosmetics, a research lab in Switzerland.
[18][19][20] Vbeauté sold a wide range of luxury skin care products, known for containing the Alpine Rose as a main ingredient.
[29] Macklowe partnered with Scottish distiller and blender Ian MacMillan, known for his work with Bunnahabhain and Bladnoch.
[25][2] Jean-Georges’ restaurants, Marea, Carbone, Le Pavillon, Casa Cipriani, and Bemelmans at the Carlyle all serve the brand.
[14] In December 2022, Macklowe's 45th birthday party made headlines for its high-profile 600-person guest list and risqué dress code of "leather and lingerie".
[37] Macklowe has been photographed at various social and philanthropic events wearing a range of designers including Dolce & Gabbana, Calvin Klein, Balenciaga and Oscar de la Renta.
[44] Early in her career, Macklowe created the “Learn to Invest” class for the all-girls Cathedral High School in New York.
[52][53][54][55] After Hurricane Sandy hit New York, Macklowe and her family offered to take refugees into their Upper East Side home.
[citation needed] Macklowe sits on the advisory board of the University of Virginia McIntire School of Commerce.