Born in Asunción, Dos Santos started his professional career with Cerro Porteño, before eventually moving to FC Bayern Munich of Germany, in January 2006.

This led to widespread rumours of his departure from the club; the speculation ended in December 2006, when Bayern announced they had reached a deal to send the player on loan to fellow Bundesliga side VfL Wolfsburg for the remainder of the season.

However, after the arrivals of Franck Ribéry, Hamit Altıntop, José Sosa and Zé Roberto, it soon became clear that he would again struggle to find a place in the first team.

Ottmar Hitzfeld, who had replaced Magath as Bayern manager by that time, stated that the club sought to sell dos Santos.

[5] A Paraguayan international since 2004, dos Santos appeared for the nation at the 2006 FIFA World Cup in two matches, assisting for the first goal against Trinidad and Tobago (2–0).