5APA44465973ENSG00000198363ENSMUSG00000028207Q12797Q8BSY0NM_001164755NM_001164756NM_004318NM_020164NM_032466NM_032467NM_032468NM_001177854NM_001177855NM_001177856NM_001290367NM_023066NM_133723NP_001158227NP_001158228NP_004309NP_064549NP_115855NP_115856NP_115857NP_001171325NP_001171326NP_001171327NP_001277296NP_075553NP_598484Aspartyl/asparaginyl beta-hydroxylase (HAAH) is an enzyme that in humans is encoded by the ASPH gene.

[5][6][7] ASPH is an alpha-ketoglutarate-dependent hydroxylase, a superfamily non-haem iron-containing proteins.

Alternative splicing of this gene results in five transcript variants which vary in protein translation, the coding of catalytic domains, and tissue expression.

Variation among these transcripts impacts their functions which involve roles in the calcium storage and release process in the endoplasmic and sarcoplasmic reticulum as well as hydroxylation of aspartic acid and asparagine in epidermal growth factor-like domains of various proteins.

[7] As early as 1996, the over-expression of HAAH was recognized as an indicator of carcinoma in humans.