From here it heads east then reaches Quenemo, where it turns north and intersects K-268.

Four miles west of Louisburg, K-68 intersects with US-169 and K-7, it also provides an end terminus with K-33 in Franklin County.

[2][3][4] The Kansas Department of Transportation (KDOT) tracks the traffic levels on its highways, and in 2018, they determined that on average the traffic varied from 270 vehicles per day slightly west of Quenemo to 12,200 vehicles per day slightly east of US-69.

[10][11] In a May 26, 1937 resolution K-68 was extended further east from US-69 to the Missouri border, which was first approved in a March 29, 1937 meeting.

[12] In a March 12, 1963 resolution, a 9.997 miles (16.089 km) section of K-68 was realigned northwest of Paola to eliminate two curves.

[17] On May 21, 2019, the highway was closed north of Quenemo, due to flooding from Salt Creek.