KPXJ (channel 21) is a television station licensed to Minden, Louisiana, United States, serving the Shreveport area as an affiliate of The CW.

The UHF channel 21 allocation was contested between multiple groups that competed for approval by the Federal Communications Commission (FCC) to be the holder of the construction permit to build and license to operate a new television station on the third commercial UHF allocation to be assigned to the Shreveport–Texarkana market (assigned to the Shreveport suburb of Minden, Louisiana).

Among the prospective applicants were John E. Powley (who applied for the license on January 16, 1996), Tucson, Arizona–based Northwest Television Inc. (owned by company president William L. Yde III, president, who applied for the license on January 18, 1996) and five parties who each applied for individual applications on April 4 and 5, 1996: Los Angeles–based Venture Technologies Group LLC (majority owned by Lawrence Rogow, who also served as the group's president), Little Rock–based Kaleidoscope Partners (forerunner company to Equity Broadcasting), Washington, D.C.–based WinStar Broadcasting Corp. (owned by Stuart B. Rekant), Wichita, Kansas–based entrepreneur Marcia T. Turner, Columbia, South Carolina–based Universal Media (majority owned by company president Murray Michaels) and Shreveport-based Word of Life Ministries Inc.[2][3][4][5] On December 19, 1997, West Palm Beach, Florida–based Paxson Communications (now Ion Media Networks) – which was preparing to launch Pax TV, a family-oriented broadcast television network, that tapped Paxson Communications-owned affiliate stations of the Infomall TV Network (inTV), and newly launched and purchased stations to serve as the network's initial affiliates – reached a settlement with the other applicants to acquire the construction permit to operate UHF channel 21, among seven it settled to acquire for an average cost of $4.95 million.

On May 1, 2004, KTBS-TV parent KTBS, LLC re-assumed operational responsibilities for channel 21 under a local marketing agreement with Minden Television.

As the duopoly partner of KTBS, the station may also simulcast long-form severe weather coverage from the ABC affiliate in the event that a tornado warning is issued for any county in its Ark-La-Tex viewing area.

In September 2000, in conjunction with the joint sales agreement that Paxson had signed with KTBS-TV, KPXJ began airing tape delayed rebroadcasts of that station's 5 and 10 p.m. newscasts Monday through Fridays at 5:30 and 10:30 p.m. (the latter beginning shortly before that program's live broadcast ended on channel 3).

Channel 21 was one of a handful of Pax-owned or -affiliated stations that maintained a news share agreement with an affiliate of a broadcast network other than NBC; most of the agreements forged between Pax TV and local broadcast stations during the early 2000s involved an NBC affiliate, by way of that network holding a minority ownership interest in Pax.

The rebroadcasts were discontinued on September 1, 2003, coinciding with the station's assumption of the UPN affiliation and the transfer of KPXJ to the Wray family's stewardship.

Three months later in December 2005, DirecTV added KPXJ to the local stations it made available to the satellite provider's subscribers in the Shreveport–Texarkana market, followed by Dish Network in April 2007.