Rupert Gunnis states that the suburb took its name from a farm that produced clotted cream.

In 1878 when the British arrived, they found that the Venetians had diverted the river Pediaios north of the city, but the old riverbed still ran through the centre, creating an open sewer and rubbish dump, which sometimes flooded into the surrounding streets.

[4] The Cyprus Government Railway (Section 1) was constructed in 1905 and the line passed through Kaimakli towards Nicosia .

A Station Halt and siding was then built in 1909 at the corner of what is now Synergasias Street and St. Hilarion.

[6] The Regis Milk Industries, a major ice cream producer on the island, has its factory located at 1 Synergasias Street.