Kallikrein

Kallikreins are responsible for the coordination of various physiological functions including blood pressure, semen liquefaction and skin desquamation.

[1] The caterpillar known as Lagoa crispata contains poison glands attached to hypodermic spines, which produce and inject venom that has been characterized as kallikrein in nature.

[3] KLK1 are very similar to serine protease found in venomous snakes like vipers, and have evolved in parallel from a common toxin precursor,[4] which cause hypotensive effects in vivo.

[citation needed] Plasma kallikrein liberates kinins (bradykinin and kallidin) from the kininogens,[6][7] peptides responsible for the regulation of blood pressure and activation of inflammation.

[citation needed] Ecallantide, lanadelumab, and berotralstat are FDA-approved drugs that inhibit kallikrein and can be used for managing hereditary angioedema.