At Main Campus, the central administration for the University is located and all general education courses are taught.

It has 135,000 square meters and houses 105 laboratories, including aerospace and underwater robotics labs, 72 classrooms, sports center, retail and food outlets, and multi-story parking.

In July 2024, the Abu Dhabi Investment Office (ADIO) and Khalifa University awarded a project through its public-private partnership program to develop world-class student accommodation and facilities in the UAE capital.

Awarded to a consortium named KUnnected Living, made up of Plenary Group, Besix and Mazrui International.

[14] It has student residences, exercise rooms, sports courts and fields, dining facility, cafeterias, two libraries, and an Independent Learning Center (ILC).

[16] Khalifa University offers a range of competitive Scholarships to Undergraduate and Graduate UAE Nationals and international students.

Scholarships by external sponsors support both UAE National and international students pursuing their degrees at Khalifa University.

[34] In February 2024, the ELT Group and Khalifa University signed an MoU (Memorandum of Understanding) to expand the knowledge of the management of the Electromagnetic Spectrum in the UAE.

[35] In 2023 within the framework of the memorandum of understanding (MoU) signed earlier to establish academic cooperation in developing aeronautical education and related research in the UAE, Khalifa University of Science and Technology and Dassault Aviation of France announced they are collaborating on a research project that focuses on developing two new material technologies for aerospace applications with potential for patenting and commercialization.

[41] In July 2024, Khalifa University launched a dual PhD program in the field of Biomedical Sciences and Engineering, in partnership with KU Leuven of Belgium, providing students from both institutions the opportunity to gain international research experience.