The station was built in 1907 as part of an extension to the Kharkiv-Mykolaiv rail line.

On November 11, 1915, Tsar Nicholas II visited the station with his heir Alexis.

On February 24, 2022, all train service from the station halted with the Russian invasion of Ukraine.

Following the Liberation of Kherson in November 2022, Ukrainian Railways and United24 launched "Tickets to Victory" in Kherson station to sell charity tickets and help raise funds for the Armed Forces of Ukraine.

[3] Two trains leaving for Lviv[4] and Mykolaiv[5] were delayed, but both arrived safely.