In the story, Knull and his symbiotes invade Earth, leaving Eddie Brock / Venom, the Avengers, the X-Men, and numerous other superheroes to protect it.

At the time when the Guardians of the Galaxy were investigating the death of Zn'rx Emperor Stote during the Galactic Council's meeting at the Proscenium and find that the Chitauri Peacekeeper and the Elders of the Universe member Profiteer were responsible sometime after the events of the "Empyre" storyline, Zoralis Gupa of the planet Silnius takes an urgent call while mentioning to the person on the other side to warn all neighboring systems.

[1] Emperor Hulkling dispatched Talos to investigate the Kree and Skrull bases that went dark with Av-Rom, Keeyah, M'lanz, Virtue, and Tarna.

After recuperating in the sick bay, Talos recaps to Kalamari about what happened on his mission that involved an encounter with Knull.

When the machine causes Uatu to overload it with psychic energy upon it mentioning about Knull, Kang's ship is destroyed leaving him adrift in space.

The Avengers and the Fantastic Four arrive to combat the Symbiote Dragons while Eddie places Dylan in the same bunker that was used by Ezekiel Sims which Spider-Man loaned to him.

As Captain America tells Venom to go to Plan B, the Avengers and the Fantastic Four work with Spider-Man, Doctor Strange, Daredevil, Iron Fist, and Luke Cage into fighting the Symbiote Dragons while making use of lightning which weakens them.

After Eddie pays a visit to the ruins of the Spire that was used as Dark Carnage's lair, he notes that Knull will work to take control of the Venom symbiote again.

Breaking free from the Symbiote Hive, Eddie warns everyone that Knull is coming with the Symbiote-possessed Celestials Arishem the Judge and Tefral the Surveyor.

Knull then proceeds to have his Symbiote Dragon form a sphere around Earth to cut it off from the Sun and has the living abyss swallow some of the superheroes including Storm which Professor X reacts to.

Eddie is then dropped by Knull into the symbiote-covered streets below as Captain America, Daredevil, Doctor Strange, Iron Fist, Ms. Marvel, Storm, and Thing are possessed by the Symbiotes.

Human Torch shoots a fire blast and tells Spider-Man to take Eddie to the Fantastic Four lab so he can get treated.

Spider-Man takes Eddie Brock to the Fantastic Four lab while Human Torch buys them time before being possessed.

The two of them go to the Fantastic Four lab where Blade is arguing with Professor X and Magneto while Black Panther is talking to Reed Richards, Sue Storm, and Jane Foster on what to do.

Iron Man tells the heroes that he has a plan which is to acquire a small part of a symbiote dragon, have Namor wake up the Black Tide (the ancient Atlantean warriors from Namor's teenage days) in the Mariana Trench, have Blade go to Chernobyl in Ukraine to persuade Dracula to help them, and persuade Mayor Wilson Fisk to hire villains to help defend New York City leading to Mayor Fisk to pay a visit to the Bar with No Name.

Iron Man arrives to use his Extremis-infected Symbiote dragon in order to take control of the symbiote-possessed Celestials.

Namor, Thor and Storm deal heavy damage, while Jean Grey immobilizes Knull with her psychic powers.

With their weapons separated from the battle axe form, Thor and Silver Surfer noted that things will not be back to normal soon.

As Iron Man takes off advising him to not let go of the magic in the world, Doctor Doom is left to wonder if Santa Claus could be a Sorcerer Supreme.

[11] Mayor Wilson Fisk decides to put together his own team of superpowered operatives to beat back Knull's creatures and save the city.

He secretly meets with eight of these operatives, all known criminals who have been working in the city without Kingpin's blessing: Taskmaster, Mister Fear, Batroc the Leaper, Rhino, Star, Ampere, and Snakehead.

To pay Mayor Fisk back, these criminals must escort Star (current keeper of one of the Infinity Gems) into battle to kill Knull, but to do that they'll first need to make contact with a man Kingpin believes can help turn the tide against the god.

The team escapes to a fishing boat nearly leaving Batroc behind and finally reach their destination: Ravencroft Institute.

Inside, they find the man Mayor Fisk believes can defeat Knull: notorious supervillain and former Thunderbolts leader Norman Osborn.

[12] Norman Osborn and the Thunderbolts make their way through Ravencroft amidst the Symbiote attacks where they joined up with Figment, Foolkiller, Grizzly, Man-Bull, and Mister Hyde.

[13] Osborn then leads the Thunderbolts into retrieving Sentry's corpse so that it can be used as a nuke to destroy Knull's lair on top of the Empire State Building with it being a suicide mission.

While fighting a Symbiote Dragon, Spider-Man runs into Reptil in his Pteranodon form who is carrying an old woman named Mrs. Volkov who he is trying to get home.

Spider-Man then gets an idea as he helps Mrs. Volkov onto the ferry while Reptil dives into the water and emerges as a Mosasaurus which bites into the Symbiote Dragon and drags it underwater.