The story centers on the invasion of Earth by an army of symbiotes and the efforts of Venom, Spider-Man, and Scarlet Spider to stop them.

[2] While teamed with Spider-Man against a terrorist group, Brock realizes the Venom symbiote is influencing him to kill.

[9] The conclusion in Web of Spider-Man Super Special #1 (Oct. 1995) finds Carnage seeking out Venom to kill him.

Spider-Man and Scarlet Spider fight Carnage while Venom attempts to create a more powerful telekinetic scream to subdue the symbiotes.

Spider-Man and Scarlet Spider defeat Carnage and Brock fully bonds with his symbiote to create the necessary scream.

[10] A trade paperback book collecting the story arc was released in August 2018 under the title Venom: Planet of the Symbiotes.