The Klehini River is a large, glacially fed stream in the vicinity of Haines in the U.S. state of Alaska.

The name Klehini appears to be derived from the Tlingit phrase l’éiw héeni, which translates to river with sand or gravel in it.

The lower Klehini is located within the Alaska Chilkat Bald Eagle Preserve.

The Klehini and Chilkat Rivers were listed among America's Most Endangered Rivers in 2023 due to threats from the Palmer Project, a proposed underground copper and zinc mine sited upstream from the Tlingit village of Klukwan.

If built, the project is feared to result in pollution from acidic wastewater laced with heavy metals and hydrocarbons.