Knoxville is an unincorporated community in Franklin County, Mississippi, United States.

Knoxville is located on the former Yazoo and Mississippi Valley Railroad.

[2] The community was incorporated in 1886 and named for Knoxville, Tennessee.

[3] A post office operated under the name Knoxville from 1849 to 1955.

This Franklin County, Mississippi state location article is a stub.