The Kuzitrin River (Kurritqiun in Inupiaq) is a stream, 95 miles (153 km) long, on the Seward Peninsula in the U.S. state of Alaska.

[1] It begins at Kuzitrin Lake in the central region of the peninsula and flows 95 miles (153 km) west into the Imuruk Basin.

[1] The basin drains via the bay of Port Clarence to the Bering Sea.

[3] Kuzitrin tributaries include the Noxapaga, Kougarok, Kruzgamepa (Pilgrim), and Kugruk rivers.

[3] The river's name, from Inupiaq, was recorded in 1900 by the United States Geological Survey.