[6] The Kvichak is navigable along its entire length, and is used as a short cut by boats getting between Cook Inlet and Bristol Bay via the Lake Iliamna portage.

The Kvichak River is home to the largest red salmon run in the world.

Commercial harvests are worth hundreds of millions of U.S. dollars annually.

The Kvichak River is part of the watershed downstream of the proposed Pebble Mine.

Historically, the river was navigated and subsistence fished by local Alaska Natives.