A native of Cherry Hill, New Jersey, Adofo-Mensah attended and earned his bachelor's degree in economics from Princeton University, where he would also walk-on to the basketball team.
Before beginning with the NFL, Adofo-Mensah had several ventures as a portfolio manager and commodities trader on Wall Street.
[2] In 2013, Adofo-Mensah began his NFL career with the San Francisco 49ers – under general manager Trent Baalke and head coach Jim Harbaugh – following a chance meeting with the team's executive vice president of football operations and NFL cap and contract manager Paraag Marathe.
[3] In 2017, Adofo-Mensah was retained under new general manager John Lynch and was promoted to director of football research and development.
On May 15, 2020, Adofo-Mensah was hired by the Cleveland Browns as their vice president of football operations under general manager Andrew Berry.