He began his NFL career as an intern for the Minnesota Vikings in 2001 before serving in the scouting department for the Houston Texans during their inaugural season in 2002.
He would go back to the Patriots in 2006, where he served various executive roles with them and as director of player personnel for the Tennessee Titans before being named general manager of the Cardinals in 2023.
He was a temporary host of the popular student radio program "SportsShow" Sunday mornings on K-UMM 89.7 the "U-90 Alternative."
In 2002, Ossenfort was hired by the Houston Texans as a pro personnel intern under general manager Charley Casserly.
In 2003, Ossenfort was hired by the New England Patriots as a personnel assistant under head coach and de facto general manager Bill Belichick.