La Penusca is an unincorporated community in Cameron County, Texas, United States.

[1] It is located within the Rio Grande Valley and the Brownsville-Harlingen metropolitan area.

La Penusca consisted of a few scattered farms in the late 1940s and had 27 homes in 1983.

[2] La Penusca is located on the shore of the Resaca de los Cuates, 1 mile (1.6 km) west of Los Fresnos in central Cameron County.

[2] Today, the community is served by the Los Fresnos Consolidated Independent School District.