La Roque-sur-Pernes (French pronunciation: [la ʁɔk syʁ pɛʁn], literally La Roque on Pernes; Occitan: La Ròca de Pèrnas) is a commune in the southeastern French department of Vaucluse.

In 2020, it had a population of 417.

After the Second World War hundreds of Banat French people from Banat, a region between Romania, Serbia and Hungary, settled in the village.

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