[4] Her initial storyline saw her son's girlfriend, Jac Naylor, embark on an affair with Anne-Marie's husband and Joseph's father, Lord Byrne - eventually culminating in his death, and leaving the character a widow.
[6] Series 8 of Holby City saw the introduction of regular character Joseph Byrne (Luke Roberts), a new Surgical Registrar on the hospital's Cardiothoracic ward, Darwin.
[7] One series 9 plot strand saw Joseph begin to date fellow Surgical Registrar Jac Naylor, unaware that she was only interested in him for his father's influence.
"[4] Series producer Diana Kyle was asked in November 2007: "When you cast an actor, do you actively seek out well-known names - like Jane Asher [Lady Byrne] and Patsy Kensit [Faye] - or will a role simply go to whoever's better suited?
[14] Although Harry was reintroduced in the show's tenth series, neither of Anne-Marie's other two sons have been mentioned since, despite the death of both their father and brother Asher has described Anne Marie as "a strong character".
[5] Jac later worries when she discovers Anne-Marie is on the interview panel for a Consultant's post she is applying for, but her fears are proved needless when Lady Byrne supports her application regardless of their shared history.
[18] In episode "My Aim is True", it is revealed that Anne-Marie works for the Byrne Foundation, a charity founded by her husband for the purpose of research into Cardiac Valve Disease.
We'll have to see that emerges - but there's potential..."[4] Anne-Marie's younger son Harry is admitted to Holby City Hospital in episode "Physician, Heal Thyself", having deteriorated in his comatose state.
[21] As Anne-Marie is attending a conference on coma patients in Paris at the time, Joseph cares for Harry in her absence, admitting that he believes himself to be at blame for his brother's condition.
[23] In episode 28 of the show's tenth series, the character returns to Holby City Hospital, and is disappointed to discover her late husband's charity is in decline.
"[4] In episode 37 of the same series, Lady Byrne held an event to celebrate the anniversary of a piece of ground breaking heart surgery, of which her deceased husband aided in.