Lafayette High School opened September 7, 1960,[7] in one small building in Ellisville.

[8] To handle the growing student body, the school moved in 1989 to Wildwood.

[10] Sports and activities include cross country, field hockey, football, golf, soccer, softball, swimming & diving, tennis, volleyball, basketball, wrestling, baseball, lacrosse, track & field, water polo, Jam Bands, Lafayette Regiment Marching Band, Student Publications, Vocal Groups, Yearbook, AFJROTC, Book Club, esports, FCA, HOSA, Jewish Students Union, Mock Trial, Mu Alpha Theta, Photography Club, Premier Chamber Strings, Racquetball Club, Robotics, Senior Women, Thespians, Winter Colorguard, Asian American Association, French Club, Latin American Culture club, Key Club, Speech and Debate Team, Student Council, National Honor Society, Cheerleaders, Escadrille, Super Fans, and Lafayette Science Council.

The Lancer Regiment performs locally at many shows and participates at the Greater St. Louis Marching Festival at the Edward Jones Dome.

[13][failed verification] The school's print yearbook, The Legend, is in its 48th year of publication.