Lake Nona High School stands as one of the more challenging schools in Orange County due to its rigorous academic workload, significantly high AP Enrollment and its open dual enrollment program through Valencia College.

In addition to the school's collegiate focus, students have the ability to attend a fast track nursing program, Health Science Academy starting their freshmen year.

In Spring of 2012, Lake Nona High School allowed Valencia College students to go there while the new Valencia College was being built.

The students from Valencia College were there until the new building was fully constructed in August 2012.

The 377,000-square-foot (35,000 m2) campus includes ten buildings consisting of one and two-story concrete, tilt-wall construction housing administration, classrooms, art and music rooms, kitchen, multi-purpose and dining facility, auditorium, gymnasium, playing fields and outdoor activity areas.