[4][5] After serving as a radar operator in the Army Air Forces during World War II,[6] Eisenberg married Frances Brenner, a political scientist and social worker, in 1950; she died in 2017.

[4] Eisenberg was for many years a biomedical engineer at Rockefeller University,[7] where he and Dr. Robert Schoenfeld were co-heads of the Electronics Laboratory, and taught there until 2000.

[9] Eisenberg published his first short story, "Dr. Beltzov's Polyunsaturated Kasha Oil Diet", in Harper's Magazine in 1962.

"[3] Many of Eisenberg's stories feature his character Professor Emmet Duckworth, a research scientist and two-time winner of the Nobel Prize.

Duckworth's "bright ideas seem great at first but always end in disaster"[11] with one of the professor's many inventions being "an addictive aphrodisiac clocking in at 150,000 calories per ounce —along with a propensity to turn those taking it into walking bombs.

Eisenberg is best known for his short story "What Happened to Auguste Clarot?," which was published in the anthology Dangerous Visions edited by Harlan Ellison.

[13] Eisenberg wrote the following limerick about his life A nonagenarian, I, A sometime writer of sci-fi, Biomed engineer, Gen’rally of good cheer,