Lespedamine, also known as 1-methoxy-N,N-dimethyltryptamine (1-methoxy-DMT or 1-MeO-DMT), is an indole alkaloid and substituted tryptamine present in the plant Lespedeza bicolor.

[1][2] The alkaloid bears a close structural resemblance to the psychedelic alkaloid dimethyltryptamine (DMT) and it was speculated by Alexander Shulgin in TiHKAL that it might be psychoactive.

[3] No reports on lespedamine's biological activity are known to have been published.

[3] Hamilton Morris asked entheogen ethnobotanist Jonathan Ott about lespedamine and its possible activity during an interview, but Ott was unfamiliar with it.

This article about an alkaloid is a stub.