[1] On 22 November 1999, three days before the series première, then director of Channel 4 Gub Neal called for the BBC to cease production of its drama programmes.
Neal highlighted Holby City as an example of the station's "safe" programming, denouncing what he perceived to be the abandonment of quality productions in favour of star-led series and "an endless soup of indistinctive programmes".
[2] Reviewing "Search for the Hero", The Guardian's Nancy Banks-Smith commented on the series' casting: "I had the uneasy sensation that I had met half these people before in assorted soap operas.
"[4] Natasha Joffe too was critical of the series' writing, opining that Holby City seemed "a bit soggy" following Nick's departure, and criticising the "Casualty-esque love of didactic plot mirroring" between the doctor and patient storylines.
Returning from the show's first series were George Irving as consultant Anton Meyer, Michael French and Dawn McDaniel as registrars Nick Jordan and Kirstie Collins, Lisa Faulkner as senior house officer Victoria Merrick, Sarah Preston and Angela Griffin as ward sisters Karen Newburn and Jasmine Hopkins, Nicola Stephenson as nurse Julie Fitzjohn, and Ian Curtis as senior staff nurse Ray Sykes.