Leukotriene-A4 hydrolase

[1] It is a bifunctional zinc enzyme (EC 3.3.2.6) with different amino acids attached to it to aid in the catalysis of the reaction.

Leukotriene-A4 hydrolase is a cytosolic protein and is found in almost all mammalian cells, tissues and organelles that have been examined.

The second carbon involved in the epoxide ring remains the same resulting in leukotriene B4.

The water molecule attacking the double bond also forms into a hydroxy group after work-up.

As of late 2007, 4 structures have been solved for this class of enzymes, with PDB accession codes 1GW6, 1H19, 1HS6, and 1SQM.